Exploring GLP1 Medications and Natural Alternatives

In recent years, GLP1 (glucagon-like peptide-1) medications have become a popular treatment option for many individuals dealing with type 2 diabetes and obesity. These medications mimic the effects of the hormone GLP-1, helping to manage blood sugar levels and control appetite. While these drugs can provide meaningful benefits, they also have some drawbacks. This blog post examines the pros and cons of GLP1 medications, explores the possibility of stopping their use, and suggests natural alternatives for managing diabetes and weight.

What is GLP-1?

GLP1 (glucagon-like peptide-1) is a hormone created naturally within our bodies. It is released from the gastrointestinal tract when we eat. As sugar levels rise when carbohydrates are broken down into simple glucose (sugar) in the bloodstream, GLP1 is triggered to release insulin from the pancreas into the blood stream. Insulin then carries gludose out of the bloodstream and into your cells to be used as nourishment and energy.

What is Diabetes and how is GLP-1 used?

Type-1 Diabetes is an autoimmune disease where your body doesn't manufacture enough insulin. Immune cells erroneously attack beta cells that produce insulin located in the pancreas. It's usually diagnosed in childhood and is a genetic or inherited condition. In some cases it can also arise from environmental exposure to viruses or pollution. This leads to glucose (sugars) accumulating in the blood stream and cells and organs not getting the nourishment they need to function properly.

Treatments for Type-1 Diabetes will consist of blood sugar checks throughout the day, education and support, nutritional counseling with a registered dietitian and a type of insulin therapy, where insulin is distributed directly into the body by injection or inhalation. [Note: GLP-1 is not an effective treatment for Type-1 Diabetes.]

Type-2 Diabetes is when insulin is no longer effective carrying glucose into cells (cells become resistant to insulin) or when cells cannot produce enough insulin to keep blood sugar levels within acceptable ranges. This condition accounts for 90-95% of all persons diagnosed with Diabetes.

Any person can develop Type-2 Diabetes but certain risk factors contribute to an individual developing it. Those risks include being 45 or older, family history, physical inactivity, being overweight or obese, other health conditions, such as heart disease, high blood pressure, high cholesterol, sleep apnea and polycystic ovary syndrome (PCOS), and race or ethnicity of the African, Asian or Hispanic descent.

Treatments for Type-2 Diabetes include monitoring blood sugar levels, Diabetes education, nutrition counseling with a Registered Dietitian, and medications to control blood sugar levels. GLP1 agonists, which act like GLP1 hormones, are one such medication that may be prescribed.

It should be noted that Type-2 Diabetes is preventable. Prediabetes is a condition where blood sugar levels are high, but not at a high enough point to be diagnosed as Type-2 Diabetes. Some steps that can be taken to prevent Diabetes include drinking water in place of soda, juice or other sweetened beverages, replacing highly processed foods with fruits and vegetables, increasing activity to at least 30 minutes per day 5 days a week and losing 5-7% of your total body weight. It's suggested that about 80% of individuals with Prediabetes are unaware they have a heightened blood sugar level because symptoms are rare.

Treatments for Prediabetes may include dietary changes as outlined by a Registered Dietitian, increasing activity to reach of a level of at least 30 minutes of exercise into your day 5 days a week, losing 5-7% of your total body weight and medications, one of which is Metformin.

The Pros of GLP1 Medications

Effective Blood Sugar Control

One of the main benefits of GLP1 medications is their strong ability to manage blood sugar levels. For instance, studies have shown that patients using GLP1 medications can achieve an average A1C reduction of 1.0 to 1.5 percentage points. By increasing insulin secretion and decreasing glucagon release, these drugs effectively lower blood glucose levels, making them a valuable tool for those with type 2 diabetes.

Weight Loss Benefits

Many patients experience significant weight loss while using GLP1 medications. Research indicates that individuals can lose between 5% to 15% of their body weight. These medications work by slowing gastric emptying and enhancing feelings of fullness. For those facing obesity, this weight loss can lead to improved health outcomes, including better cholesterol levels and reduced risk of heart disease.

One interesting fact regarding GLP1 medications is they are the same medication prescribed under a different name for different diagnoses. For instance, both Ozempic and Wegovy are the generic name of Semaglutide injection. However, because of FDA regulations, they cannot be prescribed for different uses with the same brand name, so Ozempic is prescribed for treating Diabetes, while Wegovy is prescribed for weight loss.

If you're interested in more examples, here is a link to a chart outlining the generic name, brand name and use of GLP1 medications available.

Cardiovascular Advantages

Recent clinical trials reveal that GLP1 medications can also offer benefits for heart health. For example, a study published in the New England Journal of Medicine found that patients taking GLP1 medications had a 26% reduced risk of major cardiovascular events like heart attacks and strokes. This aspect makes these drugs particularly attractive for patients with diabetes who face other heart disease risk factors.

Convenience of Use

GLP1 medications come in user-friendly injection pens, streamlining the administration process. Some formulations require only once-weekly injections, making it easier for patients to stick to their treatment regimen. This can lead to greater adherence and, consequently, better health outcomes.

The Cons of GLP1 Medications

Gastrointestinal Side Effects

Despite their benefits, GLP1 medications can lead to gastrointestinal side effects such as nausea, vomiting, and diarrhea. A survey indicated that over 20% of users experience these issues, which can deter continued use for some individuals. This discomfort can impact a person’s quality of life and may lead to discontinuation of the medication.

Risk of Pancreatitis

There have been concerns regarding the risk of pancreatitis associated with GLP1 medications. While this risk is relatively rare, it can be significant for certain patients, particularly those with a history of pancreatic issues. A study found that individuals taking GLP1 drugs showed a slightly increased pancreatitis risk of approximately 3%.

Cost Considerations

One major drawback is the cost of GLP1 medications. The average annual expense can reach up to $6,000 without insurance coverage, which can be prohibitive for many individuals. This financial burden prompts some to actively seek alternative and more budget-friendly options for managing their conditions.

Long-term Effects and Use

The long-term safety of GLP1 medications is still under investigation. Some patients express concerns about becoming reliant on these drugs and question whether they would be able to manage their diabetes and weight independently without medication. In addition, they are designed for long-term use, meaning an individual may be using this drug for the foreseeable future does not set well with everyone.

Stopping GLP1 Medications: What to Consider

Deciding to stop GLP1 medications requires careful consideration and should be done under the guidance of a healthcare professional. Discontinuing these medications suddenly can lead to problematic spikes in blood sugar levels. In many cases, a gradual tapering off, combined with close medical supervision, is recommended.

It’s vital to develop an alternative management plan beforehand. This alternative plan could include lifestyle changes, dietary updates, and possibly starting other medications. Working with a healthcare provider enables individuals to understand their situation better and make informed choices.

Natural Alternatives to GLP1 Medications

For those interested in natural alternatives to GLP1 medications, several effective strategies can help manage blood sugar and promote weight loss.

Dietary Adjustments

A diet low in glycemic index foods can significantly improve blood sugar control. Focus on whole foods that are high in fiber, such as leafy greens, legumes, and whole grains. These foods stabilize glucose levels and promote a sense of fullness, which can help manage weight. At InCourage Health we talk a lot about PFF - Protein, Fat and Fiber. Why? Because eating these three components together at every meal and snack promote satiety.

Regular Physical Activity

Incorporating regular exercise into your routine is one of the best ways to manage weight and blood sugar. For example, a study found that individuals who engaged in at least 150 minutes of moderate aerobic activity per week saw a significant improvement in insulin sensitivity and overall health.

Dietary Supplements

One of the most popular GLP1 alternative supplements is berberine, a substance found in Indian barberry and also known as "nature's Ozempic". It has many health benefits, including supporting metabolic syndrome and cholesterol levels, antioxidant and anti-inflammatory effects, weight loss, inhibiting cancer cell growth, strong antibacterial qualities and protects against atherosclerosis (hardening of the arteries), to name a few.

Although some suggest studies completed are inconsistent in dosage and length of trial making it difficult to determine it's effectiveness, others consider it a safe and natural approach with few side-effects to get control of your metabolic health and weight.

Wrapping Up the Pros and Cons

GLP1 medications can be extremely effective for managing diabetes and aiding in weight loss, but they also come with challenges. Understanding the pros and cons is crucial for those considering these medications. As with all options mentioned in this post, it's recommended you talk to your health practitioner to determine what is right for you.

If you are contemplating stopping GLP1 treatment, discussing it with your healthcare provider is essential. They can help you create a plan that includes effective alternatives. Dietary changes and exercise should be considered as a part of any program you choose and to lead to improved health outcomes.

As the medical field progresses, the dialogue around GLP1 medications and their alternatives will continue to expand. Your health journey is unique, and finding the right solution that fits your needs is the key to achieving long-term well-being.

How InCourage Health Can Help

You may have noticed that treatment for each type of Diabetes included nutrition counseling with a Registered Dietitian. This typically includes education of types of recommended foods and may prescribe calorie levels and/or percentage levels of protein, fat and fiber to consume. The dietitian may also include a sample meal plan but doesn't give much direction in how to make this new nutrition a part of your normal routine.

Without some direction regarding recipes, meal planning, grocery shopping, cooking, attending social gatherings, cravings, etc, it's easy to slip into what you know and what is comfortable. Add in the exercise piece and trying to lose weight, both also suggested and necessary treatments, and the level of stress can be off the charts.

Change is hard, especially when it's not necessarily initiated by our own motives, at first, anyway.

That is where Coach Dani at InCourage Health can help make this new lifestyle more manageable, breaking down tasks into small and realistic daily and weekly goals that are most important to you to reach the health and wellness goals you desire.

Apply for a Feel Better About YOU Breakthrough Session for the opportunity to work with Coach Dani. Upon receipt of the application, you will be contacted to schedule your free consult. I look forward to hearing from you!

In Courage!

Dani

Feeling out of control and stressed - eating when you know you shouldn't. Use this link to download this FREE guide, Combat Cravings with Protein, Fat and Fiber, to take control, get energized and feel better in your clothes.

This information is not intended as health advice but for educational purposes only. InCourage Health LLC recommends you discuss any health concerns and treatments with your health care provider.

Sources:

Burt, Gabrielle, MD. UC Davis Health. Diabetes and Related Disorders. December 18, 2023.

Catanese, Lisa, ELS. Harvard Health Publishing. GLP-1 diabetes and weight-loss drug side effects: "Ozempic face" and more. February 5, 2024.

Group, Edward, DC. Global Healing. Your Guide to Taking Berberine: The Best Time to Maximize Benefits. May 23, 2024.

Joaquin Lado Abeal, Jose, MD. UC Davis Health. GLP-1 Medications. October 18, 2024.

Marshall, Elaine. Carolina Total Wellness. Berberine rivals metformin for high blood sugar. December 18, 2018.

Migala, Jessica. WebMD. Can You Boost GLP-1 Naturally? July 26,2024.

United Health Care. UHC Health Matters. Understanding GLP-1 agonists: Benefits, uses and side effects.